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Molecular docking studies propounded that dimethoate interacted with SOD CAT and GR disrupting 3D structures and had shown strong affinity and interaction with genomic DNA

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The field remains in early stages requiring more research establishing optimal protocols, defining responder characteristics, proving long-term safety, and conducting large randomized trials

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Suggested causes and mechanisms include immune-mediated responses, altered drug metabolism associated with glutathione deficiency or slow acetylator phenotype, co-existing infections with cytomegalovirus (CMV) or Epstein-Barr virus (EBV), or cytokines involvement