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Kullenberg H, Rossen J, Johansson UB, Hagstromer M, Nystrom T, Kumlin M, et al

One-way ANOVA showed significant differences between the groups in terms of age ( p = 0.001), hence age was included as a covariate in between group comparisons of metabolite concentrations

In a Phase III trial in patients 6 to 12 years, the drugs pharmacokinetic and pharmacodynamic profiles were consistent with that seen in previous studies, according to AstraZeneca