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392 These findings suggest that both the proinflammatory cGASSTINGIFN axis and the anti-inflammatory cytokine IL-10 play crucial roles in mTOR-mediated mitochondrial inflammation and highlight mTOR inhibition as a potential therapeutic strategy for treating inflammatory diseases

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10.1038/nature15521 15 Casgevy and Lyfgenia (2024)

Myoblasts isolated from ACTA1 CreER/+ R26 LSL-DUX4/+ mice were induced to differentiate into myotubes in DM for 3 days, followed by 4-hydroxytamoxifen (4OH-TMX) treatment for 24 hours

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