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The worst case was actually in Washington, DC, from 2001 to 2004, and it was very similar

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Heffernan 2001a Mouse studies using chronic osmotic pump delivery showed AOD-9604 increased fat oxidation and plasma glycerol (a lipolysis marker) to a degree comparable with full-length hGH, without inducing hyperglycaemia or reducing insulin secretion

Adding AOD-9604 might bring that total to 7-8.5 kg, with the additional loss coming predominantly from fat tissue rather than lean mass

To overcome these challenges, future studies should focus on developing advanced imaging techniques, such as MRI, to track the real time biodistribution of MNPs (Remmo et al., 2024)