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Crowley, S

Similarly, beyond the well-studied roles of oxysterols and cholesterol esters, other cholesterol-derived metabolites may also contribute significantly to tumor progression and immune evasion, representing an exciting avenue for future research

This in turn induces dysfunction of tumor-specific CD8 + T cells and contributes to adaptive resistance to immunotherapies [126,127,128,129,130]

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Increased levels of free iron can form unstable iron pools, and an increase in unstable iron pools in cells can cause membrane lipid peroxidation