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A series of recent studies implicated sirtuins as potent negative regulators of fibroblast activation and myofibroblast differentiation, and sirtuin dysfunction has been linked to the pathogenesis of SSc and other fibro-inflammatory conditions 28,29,38,39,40,41,42

Certain bacteria in the gut microbiota may directly detect chemicals such as glucose, amino acids, and fatty acids 28

Led by Anders Fink-Jensen at the University of Copenhagen, this work explored the use of exenatide

Several noncoding RNAs have been implicated in the protective effects of H 2 S