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doi: 10.1002/hep.28251 58 OkazakiAGameiroPAChristodoulouDLaviolletteLSchneiderMChavesFet al

7:ENEURO.545ENEURO.519

Furthermore, it was demonstrated that the overexpression of PINK1 promoted neuronal activity and protected neuronal integrity ( A substantial body of evidence indicates the presence of mitochondrial fragmentation in neuronal cells in the brains of HD patients, in which the expression levels of the mitochondrial fission/fusion proteins Drp1, Fis1, and Mfn are significantly altered (Shirendeb et al., 2012)