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5 However, although peroxide treatment initially reduced PHD activity, prolonged exposure enhanced it

KD has been reported to increase the levels of neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF), which plays a critical role in neuronal growth, survival, and synaptic plasticity

Currently, research is focused on the development of highly selective inhibitors targeting specific HDAC subtypes, particularly HDAC6, which retain immunomodulatory activity while substantially reducing toxicity [243, 244]