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Moreover, blocking pathological interactions involving SQOR is a novel approachthe natural compound iridoside can disrupt GA50s binding to SQOR, thereby inhibiting NLRP3 inflammasome activation in ALS models (Fu et al., 2023)

[18] [17] A meta-analysis from 2014 concluded that ALCAR could only be recommended for the treatment of persistent depressive disorder if publication bias was deemed improbable