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However, when the levels of Ca 2+ in the mitochondrial matrix are high, especially during oxidative stress, as often observed in ASD patients, mPTP remains open for a longer time

Oral versus intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency: a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting (Project OB12)

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Understanding this mechanism has opened new opportunities to modulate inflammation and protect neurons in disorders like AD, PD, and HD