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FIGURE 3 The Lee group designed a novel hybrid anticancer prodrug (OSamp) that amplifies oxidative stress by depleting GSH and generating ROS (Han et al., 2017)

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Over activation of glutamate receptors and the resulting Ca 2+ overload stimulates calpains which target cytoskeletal proteins, kinases and phosphatases, membrane receptors and transporters (Xu et al., 2009