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Parkinsons disease-derived -synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotype

an antibody that specifically binds with a co-stimulatory molecule present on a T cell such as, but not limited to, CD27, CD28, 4- IBB, OX40, CD30, CD40, PD-1, ICOS, lymphocyte function-associated antigen- 1 (LFA-1), CD2, CD7, LIGHT, KG2C, B7-H3, and a ligand that specifically binds with CD83

(3) fermented and pickled foods (e.g., sauerkraut, kimchi, miso, soy products, soy sauce, and sourdough)

The deacetylation of SHMT2 at K95 by SIRT3 (Wei et al., 2018) or desuccinylation at K280 by SIRT5 (Yang et al., 2018) has been shown to enhance the enzymatic activity of this protein, and the deacetylation by SIRT3 also has been shown to stabilize SHMT2 through avoiding its autophagic degradation (Wei et al., 2018)

doi: 10.1016/j.clim.2009.04.008 22 ZhuKFanRCaoYYangWZhangZZhouQet al