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Crucially, synergistic interplay between these modalities, such as combining senolytics with epigenetic reprogramming or mTOR inhibition, should be rigorously explored to increase efficacy while minimizing unintended adverse effects

Their findings confirmed that pulmonary micrometastatic cells upregulate antioxidant genes, potentially enabling clinical detection of occult lesions and the development of eradication strategies before progression to treatment-resistant macrometastases

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Late stage PD is characterised by an increasing burden of drug refractory motor and non-motor symptoms with limited efficacy of available treatment options highlighting the pressing need for disease-modifying therapies