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Cost-Effectiveness of Different Forms of Intra-Articular Injections for the Treatment of Osteoarthritis of the Knee. PMC, 2016

The major classes of analgesics include nonsteroidal anti-inflammatory drugs (NSAIDs), opioid analgesics, local anesthetics, and gabapentinoids, each operating via distinct molecular mechanisms yet converging on the suppression of nociceptive signaling at the site of tissue injury, either along peripheral nerves or within central pain-processing pathways

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A high-quality prospective study recruited 165 POI patients who were assigned randomly to EA group, sham acupuncture group, once daily from postoperative days 1-4, or no acupuncture group