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Recent research has shown that CAFs, a significant group of stromal cells in the TME that emit HGF, trigger the HGF/c-MET pathway and its subsequent signals, thereby facilitating tumor movement and advancement

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Discussion Cellular senescence, triggered by diverse external and internal stressors, serves as a protective response that prevents the proliferation of impaired cells, thereby conferring resistance to cancer 45,468

MSTN in bone The deficiency of MSTN has been described to result in not only an enlargement in skeletal muscle mass but also an increase in bone mass