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[14] The value of betel nut production in Hunan was estimated at 30 billion yuan and growing

Flora et al., 2017

The mortality rate increased at 30.0 mg/kg body weight, from week 100 onward

In answer to the more direct question of how much nicotine per day is safe, a reasonable starting point might be, "How much nicotine might it take to poison someone?" The ECHA currently gives an "acute toxicity estimate" (ATE) for nicotine via the oral route to be 5 mg/kg bw [7] , meaning 5mg of nicotine for every kilogram of bodyweight of the person consuming the nicotine