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Moreover, L-Carnitine suppressed genes responsible for protein degradation in skeletal muscle [17] and decreased muscle RING-finger protein-1 ( MuRF1 ) and ubiquitin-protein conjugates, involved in protein catabolism, as well as increases the levels of IGF-1 and Akt1, two upstream elements in the mammalian target of rapamycin (mTOR), the main driver of protein anabolism [18]

and improved inflammation, endothelial dysfunction, insulin-resistance, genomic-damage, cognition, strength, gait-speed, and exercise capacity

10.1038/s41467-024-51875-9 67 WangY.WangX.LiuY.XuJ.ZhuJ.ZhengY.et al (2024b)

The RNA-seq data generated in this study have been deposited in the Gene Expression Omnibus (GEO) database under accession codes GSE263190 and GSE263119

Several studies reported a long-term effectiveness and safety of dimethyl fumarate monotherapy in patients with moderate-to-severe psoriasis