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Chronically elevated concentrations of reactive oxygen intermediates become indiscriminate in the proteins they oxidise

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This study has some limitations to consider when interpreting the results

It does not disrupt the interaction between dimers in the glutaminase tetramer but binds to the hydrophobic pocket between the monomer-monomer interface of the GAC, located at the junction where the N-terminal and C-terminal of the enzyme meet the catalytic domain, thereby preventing the GAC from activating conformational changes (Wilson et al., 2013

[DOI] [PMC free article] [PubMed] [Google Scholar] 143.Zhu Q., Wang K., Zhang C., Chen B., Zou H., Zou W., Xue R., Ji D., Yu Z., Rao B., et al