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Food and Drug Administration (FDA) approved Xarelto in November 2011 to reduce the risk of stroke and systemic embolism in people with non-valvular atrial fibrillation

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The activity of SCF E3 ubiquitin ligases is regulated by cullin neddylation, which disrupts inhibitory binding of cullin by CAND1 (Cullin Associated And Neddylation Dissociated 1) 33