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This apparent paradox has driven researchers to investigate the deeper mechanisms at work

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Treatment effects estimated using MI With the increasing computational awareness and capacity to develop statistical methods that provide more useful interpretations of the treatment effect, MI methods have become dominant for the reporting of recent weight management clinical trials (e.g., semaglutide obesity phase 2 trial [34] and the SCALE phase 3b trials [7, 8])

The peptide clears quickly, but the biological machinery it activates keeps running