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et al.: Integrated microbiome-metabolome analysis reveals novel associations between fecal microbiota and hyperglycemia-related changes of plasma metabolome in gestational diabetes mellitus (2020) RSC advances | DOI: 10.1039/C9RA07799E

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Some advanced users do split the dose (morning and evening) if taking higher amounts, but for most, a single daily dose is sufficient due to the relatively long half-life of NAD+ in cells