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Calcification causes blood vessels to harden and thicken, which means the heart has to work harder to pump blood around the body

Biochem J 1997

doi: 10.1038/s41591-018-0207-3 117 VinciMBurfordAMolinariVKesslerKPopovSClarkeMet al

Mentioned reactive aldehydes, as well as isoprostanes, particularly F2-isoprostanes, are bioactive compounds formed via nonenzymatic peroxidation of arachidonic acid (AA), serving as reliable biomarkers for assessing oxidative stress status in various clinical conditions 89