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[Epub ahead of print] Lee W

Although there is no close relationship between plasma VPA concentrations and the severity of CNS toxicity [11, 86], patients who ingest more than 200 mg/kg VPA and/or have plasma concentrations greater than 180 g/ml usually develop severe CNS depression

Palmitoylation acts as a checkpoint for MAVS aggregation to promote antiviral innate immune responses

Its potency plummets

Lysosomal damage is involved in various forms of cell death, such as apoptosis 6,7 , necroptosis 8,9 , pyroptosis 10,11 , and ferroptosis 12,13 , hinting that it is of great significance to the clarification of the potential mechanism of lysosomal damage and further exploration of efficient treatments based on lysosomal quality control (LQC)