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Moreover, FA cytotoxicity can be prevented by supplying the GSH-precursors N-acetyl-L-cysteine (NAC) or GSH-monoethyl ester (GSH-MEE), and it is exacerbated by inactivating cellular GSH synthesis

Biofilm-mediated resistance is influenced by several associated factors, including the high density and extracellular matrix characteristics of the biofilm, metabolic downregulation, efflux pump activity, and stress-response signaling pathways, which ultimately diminish drug permeability and effectiveness

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Duloxetine shows a similar effect, reducing REM sleep time while increasing sleep interruptions and limb movements during sleep

Nausea is primarily associated with the gastric rhythm disturbance from 3 cycles per minute, which is the normal gastric myoelectrical activity, to either increased activity (tachygastria) or decreased activity (bradygastria) [3]