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Zonula occludens-1 (ZO-1), the first TJ protein, was discovered in 1986, 12 while cingulin was identified as another peripheral element of TJ in 1989

Intracellular lipid peroxide (LPO) detection To detect the intracellular LPO content, 143B cells were incubated with PBS, Ru(II)-OH, NP2, and NP4 (Ru 10 M) for 6 h

Previous investigations have highlighted elevated NNMT expression in the liver and white adipose tissue (WAT) of diabetic mice and obese, with evidence suggesting that downregulating NNMT expression can mitigate diet-induced IR and obesity (Kraus et al., 2014