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Ischemia-induced glutamate excitotoxicity depletes cystine availability, compromising glutathione synthesis and inactivating GPX4, thereby removing the critical brake on lipid peroxidation

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It also increased the expression of energy expenditure-related genes such as UCP3, PGC1, and 3-Adr, contributing to body weight reduction in HFD-induced obese mice (Doan et al., 2015)

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The genotype of an individual does not explain the dynamic process impacted by several environmental and/or disease-related factors, however, the metabotype serves as the culmination of the genome-environment-microbiome interplay (Figure 3)

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