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These results suggested that alterations in amino acids, sphingolipids, and carbohydrates, such as L-tryptophan, sphingosine 1-phosphate, and myo-inositol, were tightly correlated with immunoinflammatory changes in the circulatory system of Chinese patients with MS

Sorafenib blocks systemic XC-mediated cystine input, causing endoplasmic reticulum stress, GSH depletion, and iron-dependent lipid ROS buildup (114)

doi: 10.3389/fmars.2025.1611271 Received 14 April 2025 Accepted 23 June 2025 Published 14 July 2025 Volume 12 - 2025 Edited by Luca Parma, University of Bologna, Italy Reviewed by Luis Poersch, Federal University of Rio Grande, Brazil Updates Copyright 2025 Tierney, Ralph, Pirozzi and Pernice