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Suzuki et al., 2005

Nearly 40% of trial participants on sibutramine experienced these side effects, while only 9% of those taking tesofensine experienced them

They may be able to bump this up over time, but it was basically set against the caffeine standard, which is also 400 milligrams

The median change in stroke volume during the three time points did not differ between the two groups ( p 2 mmol/l), with stroke volume change following passive leg raising over 10% (preload dependency), and with no contraindication to a nasogastric tube