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Description

Cell 113 , 483494 (2003)

Santambrogio, P

Pathogenic genetic variants in one of three genes encoding for amyloid precursor protein ( APP ), presenilin-1 or presenilin-2 lead to a form of the disease known as early-onset familial AD, which accounts for 510% of AD cases 1

Optimizes Metabolism & Heart Health Cellular energy & fat metabolism support

The authors also identified TXNIP 98 as an important mediator of LRRK2-G2019S pathological mechanisms, and proved that knocking-down its expression reversed the accumulation of phosphorylated -syn