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Acta Pharm Sin B 11(8):23062325 Misra A, Ganesh S, Shahiwala A, Shah SP (2003) Drug delivery to the central nervous system: a review

126 The PI3K/Akt pathway is pivotal, where insulin activation phosphorylates phosphatidylinositol 4,5-bisphosphate via PI3K to produce phosphatidylinositol 3,4,5-triphosphate, triggering Akt