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doi: 10.1007/s10096-016-2853-z 41 LiuS.AnY.CaoB.SunR.KeJ.ZhaoD

In vitro, oxidative stress activates apoptosis signal-regulating kinase 1 (ASK1), triggering downstream effectors, including JNK1/2 and p38MAPK

A 2012 study in *Nutritional Neuroscience* suggested oral glutathione may improve irritability and hyperactivity in some children, but sample sizes were limited and placebo controls were absent in many studies

The observation that restoration of the redox environment recovers ATP production and Complex I activity indicates the possibility that pharmacological agents can be designed and targeted to mitochondria to ameliorate deregulated S-glutathionylation reactions