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TB-500 has demonstrated significant angiogenic properties in multiple studies

10.1053/j.gastro.2013.01.049 Gastroenterology 212 VernochiP.Del ChiericoF.PutignaniL

This low-resolution structure however showed that the membrane-proximal IPT2 domains of the two c-MET molecules are arranged in close proximity, consistent with the common ligand-induced dimerization mechanism for RTKs 22