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P.KettererB.GuillouzoA.1995Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture.5555745579 50

Doi: 10.4103/0378-6323.120752

The first identified agent was hydroquinone monobenzyl ether (monobenzone), which induces cell death without activating the caspase cascade or DNA fragmentation.98 Rhododendrol, another phenolic compound used in skin lightening treatments responsible for an outbreak of leukoderma in Japan, promotes cytotoxicity via a tyrosinase-dependent mechanism.99 Hair dyes have also been implicated in the appearance of leukoderma, and one of the main suspects is paraphenylenediamine

In some cases, the harvest cell culture was treated with Benzonase endonuclease (Cat#: 101697, Merck KGaA, Darmstadt, Germany)

Certain chemotherapy regimens, some antibiotics if taken for long periods, and long-term use of the epilepsy drug phenytoin, carry a risk of nerve damage