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Another assumption is that a malfunction of the hypothalamicpituitaryadrenal (HPA) axis, which also contributes to the pathophysiology of depression, leads to upregulation of vitamin D receptor expression in these areas and increased vitamin D activity due to the presence of the enzyme 1-alpha-hydroxylase

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There was no benefit to the 24-week duration, and the SVR12 rates in the 12-week groups were 96% (26/27) with ribavirin and 93% (13/14) without ribavirin