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Polyunsaturated fatty acids (PUFAs) have been shown to reduce hepatic triglyceride accumulation, while diets high in the n-6/n-3 PUFA ratio and low in total PUFA content are linked to the development of fatty liver and other chronic metabolic disorders [75, 76]

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Such effects have been observed in endothelial cells, fibroblasts, monocytes, and epithelial cells, with cell-specific responses ( Hepatic ROS Production Changes in ROS production occur in response to variations in pyridine nucleotide couples over a physiological range of electrochemical potentials (Nocito et al., 2015)

Interestingly, the study also showed that cytokine production in human lung slices and human BAL fluid from in vivo studies after treatment with LPS are correlated (58), reinforcing the applicability of PCLS in investigating the molecular pathways of pulmonary inflammation

This condition causes long-term inflammation and thinning of the stomach lining, reducing acid production and B12 absorption