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What the FDA staffer described at the meeting was something entirely different, and much worse

In line with a limited permeability of the OMM, the glutathione pool of the intermembrane space of mitochondria (IMS) was described to be maintained separately from the cytosolic glutathione pool (Hu et al , 2008)

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It is also unlikely that VIP agonists would be therapeutically beneficial for restoring glandular secretion in CF, since VIP-mediated secretion is dependent upon CFTR [132]