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Description

Dihexa and its analogs bind with high affinity to HGF, induce c-Met phosphorylation in the presence of subthreshold levels of HGF, stimulate hippocampal spinogenesis and synaptogenesis equivalent with HGF [81], and promote neurogenesis and cerebro protection (data in preparation for publication)

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This evidence further supports fetal fibroblasts display a pro-regenerative phenotype

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In some embodiments, the otic formulation or composition comprises about 5% by weight of the silicon dioxide

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