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The Journal of Pharmacology and Experimental Therapeutics, 294 , 11201130

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Ion channel Piezo1 activation aggravates the endothelial dysfunction under a high glucose environment

This method demonstrated the medicinal promise of RTA-408, an artificial oleanane triterpene that inhibits oxidative stress and proinflammatory mediators, including NF-B and IFN-, by Nrf3/hO-1 activation