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For the optic nerve crush rat models, the RGC shows a reduction of GPX4 and SLC7A11 expression, increased membrane density, reduced mitochondrial cristae, and increased lipid peroxide and iron levels, indicating RGC ferroptosis after optic nerve crush (Guo et al., 2022)

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Ostermann S, Csajka C, Buclin T, Leyvraz S, Lejeune F, Decosterd LA, et al

400,401 Coupled with its role in regulating cell proliferation, AKT signaling is involved in regulating glucose homeostasis and lipid metabolism

PMID 16015422

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus