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The activation of MMPs is closely associated with oxidative stress, and ROS have been shown to promote MMP expression through the PI3K/AKT and IKK/NF-B pathways [73]

doi: 10.1101/cshperspect.a041359 171 SimonsM.LyonsD

To find out whether juglone has an affinity for any other binding site other than the glutathione binding site, we generated a slightly different model system, where glutathione was bound to ChaC1 protein at its binding site, and juglone was blindly docked to this system

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