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The test examines variants in the GLP1R gene (rs6923761), which directly affects receptor binding efficiency, and the GIPR variant (rs1800437), which influences glucose-dependent insulinotropic peptide signaling

The optimized extreme gradient boosting regression (XGBR) model delivers a test-set coefficient of determination (R 2 ) of 0.945, a mean absolute error (MAE) of 2 ) of 0.927, verifying its robust prediction performance and generalization ability

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