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In addition, cisplatin activates the non-receptor tyrosine kinase (Abl) and downstream p53 homologous protein in mouse ovarian blast cells, which continuously aggregate to cause oocyte death

Redaelli S, Bentivegna A, Foudah D, Miloso M, Redondo J, Riva G, et al

The altered barrier environment further primes the brain for immune activation and promotes the entry of danger-associated molecular patterns (DAMPs) and cytokines, contributing to disease progression