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The level of GSR, an essential enzyme that recycles oxidized glutathione (GSSG) back to the reduced form (GSH), was significantly decreased in CKD5 as compared to CVD2 (Figures 3A, I)

Its primary mechanisms include the inhibition of oxidative stress, apoptosis, liver fibrosis, inflammation, and pyroptosis, effects closely associated with activation of the Nrf2 signaling pathway [53]

doi: 10.1038/mi.2010.62 94 YuHHuangXMaYGaoMWangOGaoTet al

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Hence, the requirement of vitamin C for smokers is increased by 35 mg per day to 125 mg daily for men and 110 mg daily for women