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TBDD relies on an in-depth understanding of the structure and function of disease-related biological targets, such as proteins and nucleic acids, to design drug molecules that can specifically interact with these targets and modulate their activities, thereby achieving therapeutic effects

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however, the precise role of gut microbiota in IBDs is not fully understood yet, and some specific individual factors and variations should be considered to understand if the changes that occurred in these microbial are favorable, neutral or harmful [607]

The ultrastructure of the oocyte is modified in oncological syndromes