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In addition, discordant (oppositive) differential mRNA expression of genes associated to the IGF-1 signaling pathway has been observed in kidney samples from mice undergoing post-ischemic renal repair, compared to gene expression profiles reported in human renal cell carcinoma

It may be time to consider the possibility

Increased prevalence of metabolic syndrome in uncontrolled hypertension across Europe: the global Cardiometabolic risk profile in patients with hypertension disease survey