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Several studies have shown that H 2 S itself activates angiogenesis in cancer, 161,162,163,164 evidence that was used to develop strategies to promote the release of H 2 S and the activation of angiogenesis under certain pathological circumstances, such as wound healing 165,166 and inflammatory diseases

Thiobarbituric acid reactive substances were determined as described previously and expressed as pmol/mg of protein [44]

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Hence, the novel strategies aim to restore or replace the CFTR gene rather than treating the pathologies associated with its defect (d'Angelo et al., In general, gene therapy consists in delivering nucleic acids into a cell to replace or repress genes or biological functions

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