The virus is usually acquired during childhood and produces lifelong infections due to its ability to infect and remain latent in neurons (Kramer et al., 2003)
Interventions targeting mitochondrial dysfunction have the potential to delay the process of ageing and neurodegenerative diseases
Nature 423: 456461 Hsu YT, Youle RJ (1998) Bax in murine thymus is a soluble monomeric protein that displays differential detergentinduced conformations
In one embodiment the present invention relates to a vaccine composition comprising one or more pharmamers, wherein the one or more pharmamers has a molecular weight in the range 50,000 Da to 5,000,000 Da, such as from 50,000 Da to 100,000 Da, for example from 100,000 Da to 200,000 Da, such as from 200,000 Da to 300,000 Da, for example from 300,000 Da to 400,000 Da, such as from 400,000 Da to 500,000 Da, for example from 500,000 Da to 600,000 Da, such as from 600,000 Da to 700,000 Da, for example from 700,000 Da to 800,000 Da, such as from 800,000 Da to 900,000 Da, for example from 900,000 Da to 1 ,000,000 Da, such as from 1 ,000,000 Da to 1 ,200,000 Da, for example from 1 ,200,000 Da to 1 ,400,000 Da, such as from 1 ,400,000 Da to 1 ,600,000 Da, for example from 1 ,600,000 Da to 1 ,800,000 Da, such as from 1 ,800,000 Da to 2,000,000 Da, for example from 2,000,000 Da to 2,200,000 Da, such as from 2,200,000 Da to 2,400,000 Da, for example from 2,400,000 Da to 2,600,000 Da, such as from 2,600,000 Da to 2,800,000 Da, for example from 2,800,000 Da to 3,000,000 Da, such as from 3,000,000 Da to 3,200,000 Da, for example from 3,200,000 Da to 3,400,000 Da, such as from 3,400,000 Da to 3,600,000 Da, for example from 3,600,000 Da to 3,800,000 Da, such as from 3,800,000 Da to 4,000,000 Da, for example from 4,000,000 Da to 4,200,000 Da, such as from 4,200,000 Da to 4,400,000 Da, for example from 4,400,000 Da to 4,600,000 Da, such as from 4,600,000 Da to 4,800,000 Da, for example from 4,800,000 Da to 5,000,000 Da
The internalizing mechanism of CPPs is largely dependent on the properties of CPPs, cell types (membrane compositions and cellular machineries for uptake), transported cargos (concentration, structure, and linking methods), and the experimental conditions (pH and temperature) (Xie et al., 2020)
