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A study by (Gupta et al., 2000) used Fischer 334 rats (male with a weight between 180 and 220 g and female with a weight between 160 and 180 g) which were separated into two groups (Gupta et al., 2000)

research/study Antioxidants and Colitis: Reducing Glutathione Reduces Inflammation The Roles of GSH as a Key Antioxidant to Help Lessen GI Tract Damage Although antioxidants are widely considered to be beneficial in combatting cell disease and damage, results from a recent study suggest that reducing levels of an antioxidant in the colon may assist in the management of gastrointestinal inflammation

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Richie et al (2012), working with age related changes in selenium and glutathione levels in different lobes of the rat prostate found an increased level of oxidative stress together with decreases in selenium and the major cellular antioxidant glutathione (GSH)

Composite of Cross-Linked Chitosan Beads and a Cyclodextrin Nanosponge: A Metal-free Catalyst for Promoting Ultrasonic-Assisted Chemical Transformations in Aqueous media