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Anti-inflammatory NF-B Modulation MC1R and MC3R activation by melanocortin peptides has been shown to suppress NF-B nuclear translocation and downregulate pro-inflammatory cytokine production (TNF-, IL-6, IL-1) in macrophage and keratinocyte models, suggesting a role in cutaneous inflammatory signaling research (Luger et al., Journal of Investigative Dermatology, 1997)

Jones, et al

Rausch C, Borthakur G, Haddad F, Chien K, Hammond D, Montalban-Bravo G, Pemmaraju N, Masarova L, Yilmaz M, Andreeff M , Jabbour E, Burger J, Jain N, Ravandi F, Kadia T