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found increased levels of mitochondrial fission proteins, Fis1 and Drp1, and reduced levels of fusion proteins, Mfn1, Mfn2, and Opa1 [79]

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Many of these placebo-controlled studies have demonstrated that folic acid supplementation improved symptoms in severely depressed patients, elderly depressed and demented patients, and those with major acute depression or schizophrenia, particularly in individuals with RBC folate levels below 453 nmol/L (46)